NAF Ataxia Research Studies Currently Underway

Parvoneh Poorkaj Navas, BS, PhD

University of Washington
Genomic mouse models of spinocerebellar ataxia

Summary: Dr. Parvoneh Poorkaj Navas of the University of Washington will develop genetically altered mice that will carry a mutated protein kinase C gamma (PKC gamma) gene. Mutations in PKC gamma are responsible for SCA14, a disease in humans that is characterized by progressive incoordination of gait, often associated with 1X>or coordination of hands, speech and eye movements Dr Navas' goal is to study the pathogenesis of cerebellar dysfunction and neurodegeneration throughout the life cycle to aid in the development of treatments for SCA14 and related diseases.