Using MRI neurofeedback to enhance motor function in ataxia
The purpose of this study is to use a form of brain imaging (real-time functional magnetic resonance imaging, rt-fMRI) combined with neurofeedback, to train people with cerebellar ataxia to improve their motor function in terms of speed and accuracy.
Please call or email if you are interested in participation.
About the Study
Eligible Ataxia Types
Spinocerebellar Ataxias with and without genetic confirmation and Cerebellar Ataxia of unknown etiology
Type of Study
Interventional Trial
Clinical Trial Phase
Phase 0
Age Range
Adult 18+
Study Start Date
12/01/2022
Estimated Completion Date
12/01/2024
IRB Approval #
IRB00300264
Location(s)
Johns Hopkins University
1620 McElderry St., W102A Reed Hall
Baltimore, MD
Contact Information
Cherie Marvel
cmarvel1@jhmi.edu
410-502-4664
Josh Berenbaum
jberenb1@jhu.edu
410-387-8510
What does participation in the study entail?
The study entails one in-person visit to receive rt-fMRI with neurofeedback training. There will also be a neurological exam and cognitive tests administered during this visit. The participant will complete at-home therapy for 21 days following the visit. This will be conducted online and will last about 10 minutes per day.
What are the potential benefits for participants?
Cerebellar ataxia patients may experience improved precision of hand movements as a result of this study. However, this intervention is experimental and may not lead to any noticeable benefits.
What are the potential risks for participants?
The risks associated with the study design are relatively low in relation to anticipated benefits. Rt-fMRI with neurofeedback is a safe therapeutic tool that has been implemented in research involving clinical populations that suffer from impaired physical movement (e.g., Parkinson’s disease and stroke) with relative ease. It has also been implemented in a number of psychiatric disorders without serious incident (ADHD, addiction, anxiety disorders, and depression).
Is there financial compensation?
Yes. $100 and parking.
Is there travel reimbursement?
No.
Who is eligible?
- 18-100 years of age,
- At least 8th grade education,
- Right-handedness,
- Clinical diagnosis of progressive, degenerative cerebellar ataxia by a movement disorder specialist (cerebellar ataxia of unknown etiology, and spinocerebellar ataxias with and without genetic confirmation).
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