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Motor learning after cerebellar damage: The role of the primary motor cortex

Motor learning after cerebellar damage: The role of the primary motor cortex

The goal of this study to examine how you learn to make new movements with your arm and whether this ability is related to the activity of an area of your brain, called the primary motor cortex, where activity is altered in people with cerebellar ataxia.

ClinicalTrials.gov Link: clinicaltrials.gov/ct2/show/NCT05351255

About the Study

Eligible Ataxia Types
Spinocerebellar Ataxias, Sporadic Adult Onset Ataxia, Idiopathic Ataxia

Type of Study
Research Study

Clinical Trial Phase
N/A

Age Range
Adult 18+

Study Start Date
07/01/2022

Estimated Completion Date
06/30/2024

IRB Approval #
AEHN-IRB-2022-881

Location(s)

Moss Rehabilitation Research Institute
50 Township Line Road
Elkins Park, PA

Contact Information

Amanda Therrien
Amanda.Therrien@jefferson.edu
215-663-6329

What does participation in the study entail?

The study uses 3-dimensional motion capture equipment with virtual reality. The motion capture tracks your movements, and the virtual reality environment provides altered visual feedback about your movements. The study also uses a type of non-invasive brain stimulation called transcranial magnetic stimulation (TMS). Non-invasive brain stimulation involves applying safe, non-painful electrical current to the surface of your head in order to alter and measure the activity of the brain area underlying the stimulation. Participants will also undergo an assessment of upper and lower extremity motor abilities and sensory function. Usually, 4 research visits over the course of 6 months will be required. You may be invited to return for additional visits, if necessary. Each visit may take up to 3.5 hours.

What are the potential benefits for participants?

We hope that one day the knowledge gained in this study will help guide rehabilitation therapy for ataxia. 

What are the potential risks for participants?

The study is IRB approved and considered minimal risk. However, all volunteers are screened to make sure they are safe to receive TMS as part of the eligibility determination.

Is there financial compensation?

Yes. $20 per hour.

Is there travel reimbursement?

Yes. $0.575/mile, max $50 per visit.

We can also provide transportation for participants in the Philadelphia region at no cost.

Who is eligible?

Anyone diagnosed with cerebellar ataxia from a degenerative condition. This can be a hereditary condition, such as an SCA, or from sporadic or idiopathic condition.

Additional Information or Resources

Download the Patient Information Flyer for more information.

View Other Research Opportunities

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The goal of this study to examine how you learn to make new movements with your arm and whether this ability is related to the activity of an area of your brain, called the primary motor cortex, where activity is altered in people with cerebellar ataxia.

ClinicalTrials.gov Link: clinicaltrials.gov/ct2/show/NCT05351255

About the Study

Eligible Ataxia Types
Spinocerebellar Ataxias, Sporadic Adult Onset Ataxia, Idiopathic Ataxia

Type of Study
Research Study

Clinical Trial Phase
N/A

Age Range
Adult 18+

Study Start Date
07/01/2022

Estimated Completion Date
06/30/2024

IRB Approval #
AEHN-IRB-2022-881

Location(s)

Moss Rehabilitation Research Institute
50 Township Line Road
Elkins Park, PA

Contact Information

Amanda Therrien
Amanda.Therrien@jefferson.edu
215-663-6329

What does participation in the study entail?

The study uses 3-dimensional motion capture equipment with virtual reality. The motion capture tracks your movements, and the virtual reality environment provides altered visual feedback about your movements. The study also uses a type of non-invasive brain stimulation called transcranial magnetic stimulation (TMS). Non-invasive brain stimulation involves applying safe, non-painful electrical current to the surface of your head in order to alter and measure the activity of the brain area underlying the stimulation. Participants will also undergo an assessment of upper and lower extremity motor abilities and sensory function. Usually, 4 research visits over the course of 6 months will be required. You may be invited to return for additional visits, if necessary. Each visit may take up to 3.5 hours.

What are the potential benefits for participants?

We hope that one day the knowledge gained in this study will help guide rehabilitation therapy for ataxia. 

What are the potential risks for participants?

The study is IRB approved and considered minimal risk. However, all volunteers are screened to make sure they are safe to receive TMS as part of the eligibility determination.

Is there financial compensation?

Yes. $20 per hour.

Is there travel reimbursement?

Yes. $0.575/mile, max $50 per visit.

We can also provide transportation for participants in the Philadelphia region at no cost.

Who is eligible?

Anyone diagnosed with cerebellar ataxia from a degenerative condition. This can be a hereditary condition, such as an SCA, or from sporadic or idiopathic condition.

Additional Information or Resources

Download the Patient Information Flyer for more information.

View Other Research Opportunities

Print Friendly, PDF & Email
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