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Written by Dr. Jorge Diogo Da Silva, with notes from Sarah Donofrio and Celeste SuartEdited by Hayley McLoughlin From drugs and gene therapy, to electrical current and exercise programs: how researchers are becoming more innovative in the search for new treatments, in the lab models to test them, and in Read More…
Written by Dr. Hannah Shorrock, with notes from Dr. Amy Smith-Dijak and Celeste SuartEdited by Celeste Suart Understanding non-motor functions and factors that govern vulnerability in the cerebellum will help to inform preclinical therapy development, from CRISPR to small molecules, and provides important considerations for imaging studies. Together, these research Read More…
Written by Sarah Donofrio, with notes from Dr. Hayley McLoughlinEdited by Hayley McLoughlin On Wednesday morning, ICAR attendees heard talks covering a range of topics, all focused on research about the mechanisms and biomarkers of ataxia. Wednesday morning began with the Disease Mechanisms Plenary. The session was kicked off by Read More…
Written by Celeste Suart Edited by Hayley McLoughlin The first-ever International Congress for Ataxia Research was held in November 2022. This meeting allowed researchers to catch up on the latest ataxia discoveries and connect with colleagues around the globe. This series of Conference Recaps will share the highlights of the Read More…
Written by Dr. Hannah ShorrockEdited by Dr. Hayley McLoughlin Early involvement of patients in clinical trial design, developing innovative imaging techniques and leveraging a clear understanding of disease mechanisms will pave the way for clinical trial success in the ataxias. As the field of ataxia research moves towards clinical trials, Read More…
Written by Dr Hannah K Shorrock Edited by Dr Larissa Nitschke Splice modifying compounds can regulate whether or not gene therapy is active Gene therapy is an incredibly versatile therapeutic strategy that can be used to treat monogenic disorders. Gene therapy can inactivate or silence mutant gene transcripts, edit the Read More…
Written by Kaitlyn NeumanEdited by Dr Chandana Kondapalli To induce cell death, or to degrade sick mitochondria – that is the question: a new role for ataxin-3 as a mediator of this decision. Have you ever heard the saying: “I may look like I’m not doing anything, but on a Read More…
Written by Ronald Buijsen Edited by Celeste Suart The Late Breaking Session presents data that are high-impact, groundbreaking, innovative, and newsworthy. This session will cover insights into FA disease mechanisms, a novel screening platform and the use of natural history data in clinical trials. After announcing the ICAR 2022 award Read More…
Written by Dr. Amy Smith-Dijak Edited by Celeste Suart Let’s talk treatment. Thursday afternoon starts off with some debates about testing and administering new therapies. Later attendees will hear about the latest clinical trials for ataxia therapies. Work with patients? There is also a workshop on the SARA scale. Thursday Read More…
Written by Dr. Jorge Diogo Da Silva Edited by Celeste Suart This morning’s session looks beyond traditional drugs to new and innovative approaches for ataxia treatment, the best platforms to research ataxia in the lab, and the best symptom and quality of life scales to test them in patients. On Read More…
