Picture of the Lim lab taken in May 2022. Left to right: Chris Lee, Benjamin Sanders, Kimberly Luttik, Dr. Janghoo Lim, Dr. Neha Gogia, Luhan Ni, Ashley Owens, Victor Olmos
Principal Investigator: Janghoo Lim, PhD
Location: Yale University, New Haven, CT, USA
Year Founded: 2010
What disease areas do you research?
- Spinocerebellar Ataxia Type 1 (SCA1)
- Spinal and Bulbar Muscular Atrophy (SBMA)
- Alzheimer’s Disease and related disorders
What models and techniques do you use?
- Post-Mortem Human Tissues
- Mouse Models
- Zebrafish Models
- Fruit Fly Models
- Human Cell Models
- Next-generation sequencing approaches (RNA-seq)
- Microscopy
Research Focus
What is your research about?
Our lab focuses on better understanding what happens to cells and proteins during neurodegeneration.
In SCA1 and SBMA, we know the exact genetic mutation which causes disease. What is still unclear is all the negative consequences of these mutations that eventually lead to symptoms. We want to understand these early signs of sickness. Some of the types of questions we ask are:
- How neurons degenerate?
- Are different types of cells differently impacted by disease?
- How are the proteins that cause SCA1 and SBMA changed by mutations?
- What mutations cause other kinds of ataxia and neurodegenerative disease?
We try to take the knowledge we find from these questions and use it to develop new kinds of treatment.
Why do you do this research?
A lot of the research we do can be described as basic – we focus on fundamental questions about the earliest signs of disease in SCA1 and SBMA. We think that better understanding these critical moments of how disease happens will help us better develop new kinds of treatments!
There are no current effective treatments for SCA1 and SBMA. We want to help change that. By asking these key questions, we want to explore different ways to remedy symptoms.
Fun Facts
- Everyone in the lab has a different lab tape color to label things.
- Our lab members like to travel and have been to over 50 different countries.
For More Information, check out the Lim Lab at Yale Website.
Written by: Dr. Janghoo Lim
Edited by: Dr. Celeste Suart
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