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SCA1

Regional differences in BDNF levels provide new insights into SCA1 pathology

Written by Rana Abdelhalim Edited by Dr. Spyros Petrakis Early BDNF delivery improved cognitive and motor deficits while ameliorating cerebellar pathology in a SCA1 mouse model. Cognitive impairment, slurred speech, difficulty with balance and walking— these are all symptoms of spinocerebellar ataxia type 1 (SCA1). SCA1 is an inherited neurodegenerative Read More…

Snapshot: What are oligodendrocytes?

Oligodendrocytes are a type of brain cell that play a crucial role in insulating neurons to facilitate efficient transmission of electrical signals. Similar to the rubber coating on cords, oligodendrocytes wrap around axons with a cholesterol-rich myelin structure, which speeds up the transmission of electrical impulses. Each oligodendrocyte can myelinate Read More…

Getting ready for trials in SCA1 and SCA3 with imaging

Written by Dr. Gülin ÖzEdited by Dr. Celeste Suart Advanced Magnetic Resonance Imaging (MRI) detects brain changes before ataxia symptoms. The list of pharmaceutical companies that turned their attention to ataxias has been steadily increasing over the last decade. This is in large part thanks to exciting developments in gene Read More…

Snapshot: What is Drosophila melanogaster?

Drosophila melanogaster is the scientific name of the common fruit fly. Yes, the ones flying around your green bin on a hot summer day. You may be surprised to learn that it is a commonly used model organism in biomedical research and has made significant contributions to many fields of Read More…

Spotlight: The Lim Laboratory

Picture of the Lim lab taken in May 2022. Left to right: Chris Lee, Benjamin Sanders, Kimberly Luttik, Dr. Janghoo Lim, Dr. Neha Gogia, Luhan Ni, Ashley Owens, Victor Olmos Principal Investigator: Janghoo Lim, PhD Location: Yale University, New Haven, CT, USA Year Founded: 2010 What disease areas do you Read More…

Snapshot: What is the Medulla Oblongata?

The nervous system is made up of two main components: the central nervous system, which consists of the brain and the spinal cord, and the peripheral nervous system, which consists of nerve cells that branch off the spinal cord and connect the central nervous system to the rest of the Read More…

Decorative digital drawing of the brain

Snapshot: What is the pons?

Brainstem – the part that connects and acts as a communicator between our brain and our spinal cord. The brainstem itself is composed of midbrain, pons, and medulla oblangata. Even minor injuries or disruptions to this neural communication and this region can have devastating consequences. The pons is a horseshoe-shaped Read More…

Spotlight: The Shakkottai Laboratory

Principal Investigator: Vikram Shakkottai, MD, PhD Location: UT Southwestern Medical Center, Dallas, TX, USA Year Founded: 2010 What disease areas do you research? SCA1 SCA2 SCA3 SCA6 SCA7 What models and techniques do you use? Mouse Models Microscopy Patch-clamp electrophysiology In vivo electrophysiology Next-generation sequencing approaches (RNA-seq) Research Focus What is your Read More…

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