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Written by Anastasiya Potapenko Edited by Priscila Pereira Sena New clues into SCA1: RNA gets trapped inside toxic ataxin-1 clumps in brain cells, disrupting the production of proteins and contributing to disease. To develop treatments for human diseases such as spinocerebellar ataxia type 1 (SCA1), researchers need models that reflect Read More…
Escrito por Alexandra Putka Editado por la Dra. Pragya Goel Traducido por Daphne Rincon ¿Te sientes cansado(a)? No estás solo(a). La fatiga es un síntoma común de las ataxias espinocerebelosas y afecta la calidad de vida. Las ataxias espinocerebelosas (también reconocidas como SCAs) se caracterizan por diversos síntomas, pero la fatiga no siempre está incluida en esta lista. Clínicamente, la fatiga se define como la dificultad para iniciar Read More…
Written by Carrie Sheeler, PhD Edited by Celeste Suart, PhD Advances in wearable technology for tracking ataxia severity combine coordination changes across different types of movement. How do you know a new treatment is working? This is the key question that clinicians have to answer when developing and testing new therapies. One on one, a patient Read More…
Written by Poojashree Chettiar Edited by Pragya Goel, PhD AI and wearable tech may transform how ataxia is monitored Could everyday devices help track ataxia? Finding treatments for neurological disorders like spinocerebellar ataxias (SCAs) and multiple system atrophy (MSA-C) has been challenging. A major reason is the lack of good Read More…
Written by Jacen Emerson Edited by Hannah Shorrock, PhD Human Imaging data reveals worsening spinal cord damage in several Ataxias that can begin before symptoms start. Why does the spinal cord matter in SCA? Rezende and colleagues recently published the most thorough study of spinal cord damage in Spinocerebellar Ataxias Read More…
Escrito por Alexandra PutkaEditado por Dr Hannah K ShorrockTraducido por Ismael Araujo-Aliaga Científicos caracterizan la progresión de las enfermedades SCA1, 2, 3 y 6, y descubren que los síntomas cambian más rápido en los primeros 10 años de la enfermedad. El diseño de ensayos clínicos para enfermedades raras como las Read More…
Written by Ross Pelzel Edited by Eder Xhako, PhD and Celeste Suart, PhD Alternative splicing produces different versions of proteins that arise from the same gene. In many neurodegenerative diseases, this process results in dysfunctional proteins that lead to disease symptoms. In Shorrock et al., the authors investigate how alternative Read More…
Written by Katerina Pliatsika Edited by Hannah K Shorrock, PhD Additional proteins which interact with ATXN1 contribute to toxicity in a SCA1 mouse model. In neurodegenerative diseases, a problematic gene and its resulting protein play a crucial role in the selective loss of brain cells. However, a fundamental question remains unanswered: Read More…
BDNF stands for Brain-derived neurotrophic factor. BDNF is a protein found in the brain that belongs to the group of neurotrophic proteins. Neurotrophic means that these proteins promote the survival and growth of new neurons during brain development and the survival and function of existing neurons in the adult brain. Read More…
Written by Alexandra Putka Edited by Dr. Pragya Goel Feeling tired? You’re not alone. Fatigue is a common symptom of Spinocerebellar ataxias and affects quality of life. Spinocerebellar ataxias (SCAs) are characterized by various symptoms, but fatigue is not often included on this list. Fatigue is clinically defined as difficulty Read More…
