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Mouse Models

Snapshot: What is the parallel rod floor test?

Disease-relevant research is often first conducted in animal models such as mice. This is done to investigate the underlying disease mechanisms and to test promising treatment strategies before moving into clinical studies. The parallel rod floor test is an assay to measure motor coordination difficulties in mice. In the case Read More…

Regional differences in BDNF levels provide new insights into SCA1 pathology

Written by Rana Abdelhalim Edited by Dr. Spyros Petrakis Early BDNF delivery improved cognitive and motor deficits while ameliorating cerebellar pathology in a SCA1 mouse model. Cognitive impairment, slurred speech, difficulty with balance and walking— these are all symptoms of spinocerebellar ataxia type 1 (SCA1). SCA1 is an inherited neurodegenerative Read More…

Spotlight: The Lim Laboratory

Picture of the Lim lab taken in May 2022. Left to right: Chris Lee, Benjamin Sanders, Kimberly Luttik, Dr. Janghoo Lim, Dr. Neha Gogia, Luhan Ni, Ashley Owens, Victor Olmos Principal Investigator: Janghoo Lim, PhD Location: Yale University, New Haven, CT, USA Year Founded: 2010 What disease areas do you Read More…

Ataxina-3 e a disputa entre a reciclagem mitocondrial e a morte celular

Escrito por Kaitlyn Neuman Editado por Dra. Chandana Kondapalli Traduzido para o português por Priscila Pereira Sena Induzir a morte celular ou degradar mitocôndrias adoecidas – essa é a questão: um novo papel da ataxina-3 como mediadora dessa decisão. Você já ouviu alguém dizer: “Eu posso parecer não estar fazendo Read More…

Snapshot: What is the grip strength test?

Many daily tasks, such as writing or buttoning a shirt, require fine motor skills. One aspect of fine motor skills is muscle strength. In order to write, for example, you need to grip the pencil with the appropriate amount of force. Ataxia can involve a loss of control over fine Read More…

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