Join the Summer Match Challenge! All donations during the month of June will be matched by the Clementz-Peterson Family Fund and an anonymous donor, up to $100K. DONATE
Escrito por Ziyang ZhaoEditado por Dr. Hayley McLoughlinTraduzido para o Português por Priscila Pereira Sena Um aplicativo para celulares recentemente desenvolvido permitirá aos pacientes avaliar a ataxia em casa. Há um problema interessante em ciência frequentemente ofuscado pelos cientistas. Não é tão chamativo ou de grande interesse jornalístico como as Read More…
Disease-relevant research is often first conducted in animal models such as mice. This is done to investigate the underlying disease mechanisms and to test promising treatment strategies before moving into clinical studies. The parallel rod floor test is an assay to measure motor coordination difficulties in mice. In the case Read More…
Escrito por el Dr. Hannah K. Shorrock Editado por el Dr. Vitaliy V. Bondar La medición de los niveles de las proteínas de poliQ ATXN3 en el líquido cefalorraquídeo y plasma distingue a pacientes SCA3 de los individuos no afectados Para que los medicamentos o terapias modificadores de una enfermedad Read More…
Written by Rana Abdelhalim Edited by Dr. Spyros Petrakis Early BDNF delivery improved cognitive and motor deficits while ameliorating cerebellar pathology in a SCA1 mouse model. Cognitive impairment, slurred speech, difficulty with balance and walking— these are all symptoms of spinocerebellar ataxia type 1 (SCA1). SCA1 is an inherited neurodegenerative Read More…
Speech intelligibility refers to how many words can be correctly understood by a listener. For example, if someone says the phrase, “My name is John,” and a listener hears, “My name is Tom,” then the listener correctly understood 75% of the speech. In a formal speech evaluation, the percentage of Read More…
Chorea is a neurological disorder characterized by involuntary, unusual, and abrupt movements of the body that appear to be out of control and without purpose. The word “chorea” is originated from the Greek word “choreia,” which means “dance”, accurately depicting the jerky, dance-like movements shown by people suffering from this Read More…
Escrito por Dr. Ambika TewariEditado por Dr. Larissa Nitschke Traduzido por Priscila Pereira Sena A atividade anormal das células nos núcleos cerebelares profundos e das células de Purkinje correlacionam com o início precoce de sintomas motores em um modelo de camundongo de SCA3 O cerebelo tem um papel estabelecido na Read More…
Mass spectrometry, also known as “mass spec”, is a very useful analytical tool that is often used in science to determine the masses of different compounds in a sample. Mass spec has a variety of applications but frequently in biological sciences. It is used to determine the identity and abundance Read More…
Written by Sophia LeungEdited by Dr Hannah K Shorrock In SCA5, the N-terminus of β‑spectrin induces toxicity and therefore a new target for therapeutics to treat SCA5. The research group led by Dr. Adam Avery explored the roles a fragment of the β‑spectrin protein, the N-terminus, plays in SCA5. They Read More…
Speech not only consists of the words we say, but how we say them. That “how” is what is called prosody: the pitch, loudness, and timing of speech. The term prosody comes from the Greek word prosōidia meaning “song” or “melody.” Therefore, prosody is often viewed as the melody of speech. Read More…
